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In vitro granulocytic stem cell clonogenic capacity of marrow and spleen cells from mice infected with rauscher leukemia virus

✍ Scribed by Leonard A. Koltun; Hal Broxmeyer; Joseph Lobue; Torgny N. Fredrickson; Professor Albert S. Gordon; Vincent Gallicchio

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
333 KB
Volume
8
Category
Article
ISSN
0022-4790

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✦ Synopsis

Abstract

Bone marrow and spleen cells from early, midstage, and terminal Rauscher leukemia virus (RLV‐A)‐infected erythroleukemic mice were assessed for granulocyte stem cell (CFU‐c) clonogenic capacity in the semisolid agar culture assay. It was found that marrow CFU‐c concentrations exceeded normal in early stages of this erythroid disease but returned to near normal values during mid‐ and terminal phases. Splenic CFU‐c concentrations, on the other hand, were generally higher than control values for all stages of the disease. These results are discussed with reference to the pathogenesis of RLV‐A disease.

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Diffusion chamber hematopoiesis in marrow and spleen cells from mice infected with rauscher leukemia virus (RLV-A)
✍ Leonard A. Koltun; Dr. Joseph Lobue; Torgny N. Fredrickson; Albert S. Gordon 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 English ⚖ 305 KB

## Abstract Preleukemic and terminal phase marrow cells from RLV‐A‐infected mice placed within diffusion chambers and implanted into normal mice, maintained elevated levels of both erythroid and myeloid precursor cells, whereas normal control marrow cells grown within diffusion chambers in normal h