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In vitro expansion of DNA triplet repeats with bulge binders and different DNA polymerases

✍ Scribed by Di Ouyang; Long Yi; Liangliang Liu; Hong-Tao Mu; Zhen Xi


Book ID
111312574
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
523 KB
Volume
275
Category
Article
ISSN
1432-1327

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The expansion of DNA triplet repeats has been shown to be responsible for about a dozen hereditary diseases. In this paper we are concerned with a computer model of such expansion, applied to the fragile X syndrome and Huntington's disease, for which enough quantitative data have been collected. The