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In vitro evidence for the presence of [3H]-haloperidol uptake in rat brain

โœ Scribed by Stefania Ruiu; Giorgio Marchese; Pier Luigi Saba; Rosalba Satta; GianLuigi Gessa; Andrea Vaccari; Luca Pani


Book ID
110007570
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
140 KB
Volume
138
Category
Article
ISSN
0007-1188

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Paroxetine, an antidepressant with a high affinity for serotonin (5-HT) re-uptake sites, is a potential tracer of these sites. We determined the kinetic properties of ["Hlparoxetine in rat brain in vivo. Relative to [l4C1iodo-antipyrine, the brain uptake index (BUI) of r3H1paroxetine was 60-70%. The