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In vitro Evaluation of Hexagonal Polymeric Micelles in Macrophage Phagocytosis

✍ Scribed by Hsieh-Chih Tsai; Che-Hau Chang; Yie-Chan Chiu; Shuian-Yin Lin; Che-Ping Lin; Ging-Ho Hsiue

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
552 KB
Volume
32
Category
Article
ISSN
1022-1336

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✦ Synopsis

Abstract

This paper develops a non‐spherical polymeric micelle using an amphiphilic block copolymer and a porphyrin crystalline structure. The nanoscale polymer micelles were characterized by transmission electron microscopy (TEM) and atomic force microscopy (AFM), revealing particle sizes of approximately 150 nm with a particular shape in the hexagonal lattice. The shape shows the selective uptake efficacy for the HeLa and macrophage cells, and inhibits phagocytosis against the macrophage.

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