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In vitro elution of ciprofloxacin from polymethylmethacrylate cement beads

✍ Scribed by Dr. Frank R. Dimaio; James J. O'Halloran; John M. Quale

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
351 KB
Volume
12
Category
Article
ISSN
0736-0266

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The use of antibiotic‐impregnated polymethylmethacrylate (PMMA) cement beads for the local delivery of antibiotics in the treatment of chronic osteomyelitis has become a standard orthopaedic practice. The increasing resistance to antibiotics of organisms associated with orthopaedic infections has led to interest in the incorporation of more effective antibiotics into PMMA cement. Ciprofloxacin, a synthetic fluoroquinolone, is potent against a broad spectrum of bacteria associated with osteomyelitis. In this study, strands of ciprofloxacin‐impregnated PMMA cement beads were prepared with 0.2, 0.5, or 1.0 g of ciprofloxacin per 40 g of PMMA. The elution concentration of ciprofloxacin was at least 1–2 mcg/ml for 7 days (0.2 g), 30 days (0.5 g), and 42 days (1.0 g). This concentration is equivalent to the minimum inhibitory concentration for the common pathogens associated with osteomyelitis. Concurrent systemic and local ciprofloxacin therapy appears to be a method for the treatment of chronic osteomyelitis.

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