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In vitro effects of IL-12 and IL-2 on NK cells, cytokine release and clonogenic activity in myelodysplastic syndromes (MDS)

โœ Scribed by Sarina, B; Cortelezzi, A; Cattaneo, C; Pomati, M; Silvestris, I; Stefano, M Di; Lambertenghi-Deliliers, D; Hu, C; Monza, M; Maiolo, A T


Book ID
110053649
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
542 KB
Volume
11
Category
Article
ISSN
0887-6924

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Cytokine regulation of IL-12 receptor ฮฒ2
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The biological activities of IL-12 are mediated through a specific, high-affinity receptor composed of IL-12 receptor(R)beta1 and IL-12Rbeta2 subunits that exist primarily on T and NK cells. Remarkably, the expression of IL-12Rbeta2 on CD4(+) T cells in mouse and humans appears to be differentially