Numerous reports have shown an association between overexpression of the epidermal growth factor receptor (EGFR), and poor prognosis in head and neck squamous cell carcinomas (HNSCC), however, the underlying mechanisms are still unclear. In the present study, we set out to determine whether EGFR exp
In vitro effect of radiation, antibody to epidermal growth factor receptor and Docetaxel in human head and neck squamous carcinoma cells with mutant P53 and over-expressed EGFR
✍ Scribed by Nongnit Laytragoon-Lewin; Hasan Ustun; Juan Castro; Signe Friesland; Mehran Ghaderi; Jan Lundgren; Ingela Turesson; Freddi Lewin
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 370 KB
- Volume
- 135
- Category
- Article
- ISSN
- 1432-1335
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## Abstract High expression of the epidermal growth factor receptor (EGFR) has been implicated in the development of squamous‐cell carcinomas of head and neck (SCCHN). ZD1839 (‘Iressa’) is an orally active, selective EGFR‐TKI (EGFR‐tyrosine kinase inhibitor) that blocks signal transduction pathways
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