Since the natural history of hepatitis C virusassociated liver disease and the therapeutic responsiveness might vary according to liver and blood mononuclear cells viral levels, it may be important to quantitate viral RNA in liver, blood mononuclear cells and serum, and to compare these data with ge
In vitro effect of amantadine and interferon α-2a on hepatitis C virus markers in cultured peripheral blood mononuclear cells from hepatitis C virus-infected patients
✍ Scribed by Julio Martı́n; Sonia Navas; Mario Fernández; Miguel Rico; Margarita Pardo; Juan Antonio Quiroga; Friederike Zahm; Vicente Carreño
- Book ID
- 114145216
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 131 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0166-3542
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## Abstract The mechanisms underlying chronicity of hepatitis C virus (HCV) infection are poorly understood, but the importance of impaired viral clearance by the immune system has been suggested. The prevalence of HCV infection of peripheral blood mononuclear cells (PBMC) was in investigated in 34
In infected individuals, hepatitis C virus (HCV) exists as a variably complex population of related genetic variants known as quasispecies. The quasispecies of HCV were studied previously in 10 chronically infected patients by single-strand conformation polymorphism analysis of a segment of the enve