In vitro DNA synthesis by megaloblastic bone marrow: Effect of folates and cobalamins on thymidine incorporation and de novo thymidylate synthesis

The effect of colony stimulating factor

The effect of colony stimulating factor on the synthesis of ribonucleic acid by mouse bone marrow cells in vitro

✍ Antony W. Burgess; Donald Metcalf 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 919 KB

## Abstract The effect of granulocyte‐macrophage colony stimulating factor (GM‐CSF) on the synthesis of RNA in liquid cultures of mouse bone marrow, spleen, thymus, peritoneal, peripheral blood leukocytes and lymph node cells was investigated. GM‐CSF appeared to stimulate RNA‐synthesis in syngeneic