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In vitro degradation of amyloid material by four proteases in tissue of a patient with familial amyloidotic polyneuropathy

✍ Scribed by Noriaki Adachi; Chang-Sung Koh; Naoyuki Tsukada; Shin'ichi Shoji; Nobuo Yanagisawa


Book ID
118930581
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
244 KB
Volume
84
Category
Article
ISSN
0022-510X

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Familial amyloidotic polyneuropathy is an inherited form of amyloidosis associated with a mutant form of a protein called transthyretin. The Methionine-30 variant is the most frequent mutation observed. This disorder is caused by deposition of this protein as amyloid in several organs, such as the h