In vitro cytotoxic evaluation of some new heterocyclic sulfonamide derivatives

✍ Scribed by Mostafa M. Ghorab; Mansour S. Al-Said; Ebaa M. El-Hossary

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2011
• Tongue: English
• Weight: 197 KB
• Volume: 48
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.619

✦ Synopsis

Abstract

Sulfonamide‐bearing compounds posses many types of biological activities and have been recently reported to show substantial antitumor activity in vitro and/or in vivo. There are a variety of mechanisms for the anticancer activity, and the most prominent mechanism is the inhibition of carbonic anhydrase isozymes. This work reports the synthesis of some new quinoline, pyrimido[4,5‐b]quinoline and 3,1‐oxazinoquinoline derivatives bearing a sulfonamide moiety. All the newly synthesized compounds were evaluated for their in vitro anticancer activity against Ehrlich ascites carcinoma cells. Compounds 10, 13, and 26 were the most active compounds with IC~50~ values of 6.1 μ__M__, 6.8 μ__M__, and 6.4 μ__M__, respectively, and exhibited better activities than the reference drug doxorubicin (IC~50~ = 68.1 μ__M__). J. Heterocyclic Chem., 2011.