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In Vitro Cytotoxic-Active Platinum(II) Complexes Derived from Carboplatin and Involving Purine Derivatives

✍ Scribed by Lukáš Dvořák; Igor Popa; Pavel Štarha; Zdeněk Trávníček


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
381 KB
Volume
2010
Category
Article
ISSN
1434-1948

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p-Isopropylbenzaldehyde thiosemicarbazone (pis.TSCN) (1) reacts with [Pt(m-Cl)(h 3 -C 4 H 7 )] 2 to form a dinuclear [Pt(m-Cl)(p-is.TSCN)] 2 complex (2) and a cyclometallated cluster [Pt(pis.TSCN)] 4 (3). Biological testing of these complexes against HL-60 and U-937 human leukemic cells suggest that