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In vitro culture reduces immunogenicity of pancreatic endocrine islets

✍ Scribed by KEDINGER, MICHELE; HAFFEN, KATY; GRENIER, JACQUES; ELOY, ROSY


Book ID
109708081
Publisher
Nature Publishing Group
Year
1977
Tongue
English
Weight
354 KB
Volume
270
Category
Article
ISSN
0028-0836

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Islet cell lines were produced by retroviral transduction of SV-40 T antigen to monolayer cultures of neonatal rat islets. One line, RN0-11, showed evolution of phenotypes in vitro. It evolved from a non-hormone secreting cell line to an insulin secreting line. It further developed glucagon producin