𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In vitro cultivation of the mouse mammary tumor virus: Correlation of infectivity and morphology with radioisotope studies

✍ Scribed by Robert D. Cardiff; Phyllis B. Blair

Publisher
John Wiley and Sons
Year
1970
Tongue
French
Weight
541 KB
Volume
5
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Organ and cell cultures of BALB/cfC3H mammary tumor tissue release infectious MTV into the medium. Not only were bioassays of culture fluid for MTV positive, but also radioisotope‐labelled MTV‐RNA and MTV B‐particle antigenicity could be detected in the culture fluid. In addition, type B virus particles were found budding from the cell membranes. Bioassays of control MTV‐free BALB/c tumor cultures were negative, as were radio‐chemical, immunological and morphological studies. Thus, infectivity could be correlated to the presence of labelled B particles in the cultures.

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