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In vitro CsG, CsA and FK506 hepatotoxicity study as a function of cytochrome P-450 3A induction

✍ Scribed by Sophie Ellouk-Achard; Chantal Martin; Chuong Pham-Huy; Huynh Thien Duc; Marc Thevenin; Hélène Dutertre-Catella; Jean-Michel Warnet; Jean-Roger Claude


Book ID
119538967
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
126 KB
Volume
88
Category
Article
ISSN
0378-4274

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Many commonly used drugs are substrates for hepatic cytochrome P-450 3A in human beings, and its role in the metabolism of potentially toxic immunosuppressants has been highlighted (cyclosporine, FK 506). One hundred fifty human liver grafts were biopsied before and after liver transplantation, and