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In vitro cross-resistance to nucleoside analogues and inhibitors of topoisomerase 1 and 2 in acute myeloid leukemia

✍ Scribed by Michael Fiegl; Inka Zimmermann; Isolde Lorenz; Wolfgang Hiddemann; Jan Braess


Publisher
Springer
Year
2007
Tongue
English
Weight
180 KB
Volume
87
Category
Article
ISSN
0939-5555

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Mutations of CEBPA in acute myeloid leuk
✍ Jennifer Snaddon; Matthew L. Smith; Michael Neat; Maxine Cambal-Parrales; Amanda πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 445 KB

CEBPA encodes the transcription factor C/EBPalpha and is specifically up-regulated during granulocytic differentiation. The gene is mutated in approximately 20% of patients with acute myeloid leukemia (AML) FAB type M2 and occurs in the absence of the t(8;21). In much the same way as specific transl