In vitro complement activation after contact with pyrolytic carbon-coated and uncoated polyethylene terephthalate
โ Scribed by E CENNI; D GRANCHI; G CIAPETTI; S STEA; E VERRI; S GAMBERINI; A GORI; A PIZZOFERRATO; P ZUCCHELLI
- Book ID
- 110372723
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 257 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0957-4530
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In order to evaluate whether or not polyethylene terephthalate coated with pyrolytic carbon and collagen (PET+PC) favors inflammatory or hyperplastic reactions, the expression of mRNAs specific for interleukin-6 (IL-6), platelet-derived growth factor-A (PDGF-A), PDGF-B, transforming growth factor-โค1
Leukocyte activation is one test for the evaluation of blood-materials interaction. The expression of adhesion molecules analyzed by flow cytometry provides a simple method to evaluate leukocyte activation by biomaterials: any change in these molecules can be predictive of the inflammatory activity