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In vitro characterization of rosiglitazone metabolites and determination of the kinetic parameters employing rat liver microsomal fraction

✍ Scribed by Leandro Augusto Calixto; Anderson Rodrigo Moraes de Oliveira; Valquíria Aparecida Polisel Jabor; Pierina Sueli Bonato

Book ID
107697988
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
232 KB
Volume
36
Category
Article
ISSN
0378-7966

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Simultaneous determination of rosiglitaz
Simultaneous determination of rosiglitazone and its metabolites in rat liver microsomal fraction using hollow-fiber liquid-phase microextraction for sample preparation
✍ Leandro Augusto Calixto; Pierina Sueli Bonato 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 271 KB

## Abstract A three‐phase hollow‐fiber liquid‐phase microextraction method for the analysis of rosiglitazone and its metabolites __N__‐desmethyl rosiglitazone and ρ‐hydroxy rosiglitazone in microsomal preparations is described for the first time. The drug and metabolites HPLC determination was carr