In vitro characteristics of highly purified factor VIII concentrates
β Scribed by Massimo Morfini
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 249 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0939-5555
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Fifty batches of Factor VIII concentrates from 12 producers were characterized in a long-term follow-up. The following parameters were measured: Factor VIII: C, Factor VIIIR: AG, Factor VIII: Rcof, specific activity (U Factor VIII: C/mg protein), fibrinogen, IgG, IgM, IgA, isoagglutinins, Hbs-AG, he
The inactivation of both transfusion-relevant and model viruses by modified pasteurisation (10 hours at 63Β°C in solution) has been evaluated following the established guidelines of the EU CPMP Ad Hoc Working Party on Biotechnology/ Pharmacy. This heat treatment was introduced into the manufacturing