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In vitro biotransformation of SDZ RAD: a new immunosuppressive macrolide in human liver microsomal preparations

✍ Scribed by R Dannecker; A.E.M Vickers; G Ubeaud; Ch Hauck

Book ID: 117236433
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 129 KB
Volume: 30
Category: Article
ISSN: 0041-1345
DOI: 10.1016/s0041-1345(98)00592-2

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## Abstract Different tacrolimus epoxides and dihydrodiol epoxides arising from the chemical oxidation of the parent drug are described. Open‐chain tautomeric forms involving the lactone function were identified for the tacrolimus epoxides. Moreover, the identification by electrospray and electrosp