In Vitro Bioactivity and Biocompatibility of Dicalcium Silicate Cements for Endodontic Use

✍ Scribed by Chun-Cheng Chen; Chia-Che Ho; Chan-Hen David Chen; Wei-Chung Wang; Shinn-Jyh Ding

• Book ID: 116677528
• Publisher: Elsevier Science
• Year: 2009
• Tongue: English
• Weight: 395 KB
• Volume: 35
• Category: Article
• ISSN: 0099-2399
• DOI: 10.1016/j.joen.2009.08.006

✦ Synopsis

Introduction:

The purpose of this study was to examine the in vitro bioactivity and biocompatibility of sol-gel-derived dicalcium silicate cements.

Methods:

The morphology, phase composition, and compressive strength of the novel cement were investigated after immersion in a simulated body fluid for different periods of time. cement biocompatibility was evaluated by incubating the cement specimens with mg63 human osteoblast-like cells.

Results:

After immersion in a simulated body fluid as little as 1 hour, the cements were covered with clusters of bone-like apatite spherulites. the characteristic peaks of apatite at 2theta = 25.9 degrees and 31.8 - 32.9 degrees appeared. the compressive strength of the cement was increased from the initial strength value of 12.3 mpa to 1-day strength value of 20.2 mpa; these values were significantly different (p < .05). the mg63 cell viability increased 15% and 23% on the cement surfaces when compared with the control on hour 6 and day 7 of incubation, respectively. the cells appeared flat and exhibited intact, well-defined morphology on the cement surface.

Conclusions:

Both bioactivity and biocompatibility of the dicalcium silicate cement consistently make it a potential candidate for endodontic use.