A bispecific monoclonal antibody (BsMAb) recognising carcinoembryonic antigen (CEA) and doxorubicin (Dox) was used in colorimetric microcytotoxicity assays with 3 human colon cancer cell lines (COLO320DM, SKCO1 and LS174T) showing no, high or medium CEA expression, respectively. The IC50 values for
β¦ LIBER β¦
In vitro binding and in vivo localization in colorectal cancer of a high affinity monoclonal antibody to carcinoembryonic antigen
β Scribed by Mr N. C. Armitage; A. C. Perkins; L. G. Durrant; I. O. Ellis; K. C. Ballantyne; R. C. Harrison; A. M. L. Riley; R. A. Robins; M. L. Wastie; J. D. Hardcastle
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 588 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0007-1323
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We describe a novel version of antibody-directed enzyme prodrug therapy (ADEPT), with the use of amygdalin as prodrug. Amygdalin is a naturally occurring cyanogenic glycoside, which can be cleaved by sweet almond β€-glucosidase to yield free cyanide. If amygdalin could be activated specifically at th