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In vitro assessment of the agonist properties of the novel 5-HT1A receptor ligand, CUMI-101 (MMP), in rat brain tissue

✍ Scribed by Nicola Hendry; Isabel Christie; Eugenii Alfredovich Rabiner; Marc Laruelle; Jeannette Watson

Book ID
116799662
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
501 KB
Volume
38
Category
Article
ISSN
0969-8051

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Flibanserin (BIMT 17) has been described as a 5-HT 1A agonist with preferential affinity for postsynaptic 5-HT 1A receptors and as a 5-HT 2A antagonist. Indeed, using the forskolin-stimulated cAMP accumulation technique, flibanserin but not the 5-HT 1A agonists buspirone and 8-OH-DPAT had agonistic