✦ LIBER ✦

In vitro assessment of immunocompetence in patients with malignant melanoma

✍ Scribed by Sidney H. Golub; Decio M. Rangel; Donald L. Morton

Publisher: John Wiley and Sons
Year: 1977
Tongue: French
Weight: 702 KB
Volume: 20
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910200609

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Ninety‐four patients with malignant melanoma and 96 healthy controls were tested for lymphocyte proliferative capacity in a microblastogenesis assay. Each lymphocyte sample was assayed for incorporation of (^3^H)thymidine after stimulation with PHA, PWM, Con A (two doses), PPD, and allogeneic lymphocytes (MLC). MLC was the only assay that revealed a substantial and significant difference between the melanoma patients and controls. Almost all assays showed lower values in patients with more advanced disease. However, it was not possible to accurately predict clinical outcome from data obtained from in vitro immunocompetence tests. These results indicate the relatively limited clinical usefulness of assays of lymphocyte proliferative capacity in melanoma patients.

📜 SIMILAR VOLUMES

Estrogen receptors in patients with mali

Estrogen receptors in patients with malignant melanoma

✍ Edward T. Creagan; James N. Ingle; John E. Woods; Douglas J. Pritchard; Nai-Sian 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 213 KB 👁 2 views

Assessment of prognosis in cutaneous mal

Assessment of prognosis in cutaneous malignant melanoma

✍ T. L. Barclay; D. J. Crockett; D. S. Eastwood; J. Eastwood; G. R. Giles 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 414 KB 👁 2 views

Multiple primary malignancies in patient

Multiple primary malignancies in patients with cutaneous melanoma

✍ Robert E. Bellet; Isaac Vaisman; Michael J. Mastrangelo; Edward Lustbader 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 633 KB

Second primary tumors in patients with c

Second primary tumors in patients with cutaneous malignant melanoma

✍ Smita Bhatia; Lilian Estrada-Batres; Tamara Maryon; Monica Bogue; David Chu 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 81 KB 👁 2 views

Several studies report coexistent or subsequent primary tumors (SPT) among patients with malignant melanoma (MM), with the rate of incidence ranging from 1.5-20% depending on the sample size and the length and completeness of follow-up. ## METHODS. The authors followed a cohort of patients with c

Metastatic disease in patients with newl

Metastatic disease in patients with newly diagnosed malignant melanoma

✍ Gary M. Zartman; Mathew R. Thomas; William A. Robinson 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB

In patients with stage I Clark's level III and IV malignant melanoma (MM), recurrence rates of 30-60% can be expected after resection of the primary lesion. If metastatic disease could be detected early and treated in such patients, survival might be prolonged. Ninety patients (37 males and 53 femal

Indirect leukocyte migration assay in pa

Indirect leukocyte migration assay in patients with malignant melanoma

✍ Lindsay J. Morrison; Alistair J. Cochran; Rona M. Mackie; Catherine E. Ross; Gay 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 588 KB

## Abstract Leukocytes from 72 melanoma patients and 75 control donors were examined in a two‐stage (indirect) leukocyte migration assay, using formalin‐fixed melanoma cells (FMC) and control, normal or non‐melanoma tumour cells (FCC) as the source of antigen. Inhibitory supernatants were produced