𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In vitro antitumor reactivity of mononuclear leukocytes from cancer patients receiving immunotherapy with BCG

✍ Scribed by Mavligit, Giora M. ;Hersh, Evan M.

Book ID
102949711
Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
665 KB
Volume
5
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

Mononuclear cell‐mediated cytotoxicity (MCMC) against cultured tumor target cells was studied sequentially in melanoma and breast cancer patients before and during BCG administration. MCMC showed temporary fluctuations. In patients with locally advanced melanoma and carcinoma of the breast after tumor load reduction, the administration of BCG may increase the MCMC. This did not always correlate with a favorable clinical course. Potentiating serum factors appeared in 50% of these patients during BCG therapy, while blocking factors were rare. Neither correlated with prognosis. In patients with disseminated melanoma receiving chemoimmunotherapy, increases in MCMC may be related to clinical course. Blocking serum factors frequently developed in this group of patients and potentiating factors were rare. Neither correlated with the clinical course. Significant MCMC among normal donors and the apparent lack of specificity suggest a common non‐specific (? natural) cellular reactivity against cultured tumor target cells.

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Sequential in vitro reactivity of lymphocytes from melanoma patients receiving immunotherapy compared with the reactivity of lymphocytes from healthy donors
✍ Jane Berkelhammer; Michael J. Mastrangelo; J. Frederick Laucius; Audley J. Bodur 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 485 KB

## Abstract A microcytotoxicity technique was used to determine the sequential in vitro reactivity against melanoma cells of lymphocytes from melanoma patients receiving immunotherapy and from healthy donors. Lymphocytes were collected every 2 weeks for 2‐3 months and were stored in liquid nitrogen