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In vitro antimalarial interactions between mefloquine and cytochrome P450 inhibitors

โœ Scribed by Raewadee Wisedpanichkij; Wanna Chaijaroenkul; Piyanan Sangsuwan; Jintana Tantisawat; Kanyarat Boonprasert; Kesara Na-Bangchang


Book ID
116182294
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
281 KB
Volume
112
Category
Article
ISSN
0001-706X

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## Abstract Studies on the binding spectra of certain alkaloids with rat liver microsomes revealed that brucine, scopolamine and strychnine are type I compounds, whereas boldine, emetine, nicotine, reserpine and sanguinarine show type II binding. In contrast, colchicine and solanine failed to produ