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In Vitro Anticancer Activity and Biologically Relevant Metabolization of Organometallic Ruthenium Complexes with Carbohydrate-Based Ligands

✍ Scribed by Isabella Berger; Muhammad Hanif; Alexey A. Nazarov; Christian G. Hartinger; Roland O. John; Maxim L. Kuznetsov; Michael Groessl; Frederic Schmitt; Olivier Zava; Florian Biba; Vladimir B. Arion; Markus Galanski; Michael A. Jakupec; Lucienne Juillerat-Jeanneret; Paul J. Dyson; Bernhard K. Keppler

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
637 KB
Volume
14
Category
Article
ISSN
0947-6539

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✍ Wolfgang Kandioller; Christian G. Hartinger; Alexey A. Nazarov; Caroline Bartel; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 388 KB

## Abstract Organometallic ruthenium–arene compounds bearing a maltol ligand have been shown to be nearly inactive in in vitro anticancer assays, presumably due to the formation of dimeric Ru^II^ species in aqueous solutions. In an attempt to stabilize such complexes, [Ru(η^6^‐__p__‐cymene)(XY)Cl]