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In vitro anti-leukaemia activity of sphingosine kinase inhibitor

✍ Scribed by Clara Ricci; Francesco Onida; Federica Servida; Franca Radaelli; Giorgia Saporiti; Katia Todoerti; Giorgio Lambertenghi Deliliers; Riccardo Ghidoni


Book ID
108676083
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
316 KB
Volume
144
Category
Article
ISSN
0007-1048

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CEP-751 inhibits trk receptor tyrosine k
✍ Anna Marie Camoratto; Jitesh P. Jani; Thelma S. Angeles; Anna C. Maroney; Christ πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 French βš– 134 KB πŸ‘ 1 views

The present report describes the in vitro and in vivo profile of CEP-751, a novel receptor tyrosine kinase inhibitor. CEP-751 at 100 nM inhibits the receptor tyrosine kinase activity of the neurotrophin receptors trkA, trkB and trkC. CEP-751 has no effect on activity of receptors for EGF, IGF-I, ins