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In vitro and in vivo testing of glucose-responsive insulin-delivery microdevices in diabetic rats

✍ Scribed by Chu, Michael K. L.; Chen, Jian; Gordijo, Claudia R.; Chiang, Simon; Ivovic, Alexander; Koulajian, Khajag; Giacca, Adria; Wu, Xiao Yu; Sun, Yu

Book ID
120980944
Publisher
Royal Society of Chemistry
Year
2012
Tongue
English
Weight
693 KB
Volume
12
Category
Article
ISSN
1473-0197

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Alloxan-induced diabetes in rats significantly impaired the capacity of the erythrocytes to metabolise glucose in vitro to either lactic acid or CO2. Both these metabolic activities were initially insensitive to insulin in normal as well as in diabetic animals; but became responsive when these cells