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In vitro and In vivo Selective Antitumor Activity of Edelfosine against Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Involving Lipid Rafts

✍ Scribed by Mollinedo, F.; de la Iglesia-Vicente, J.; Gajate, C.; de Mendoza, A. E. H.; Villa-Pulgarin, J. A.; de Frias, M.; Roue, G.; Gil, J.; Colomer, D.; Campanero, M. A.; Blanco-Prieto, M. J.


Book ID
118064273
Publisher
American Association for Cancer Research
Year
2010
Tongue
English
Weight
589 KB
Volume
16
Category
Article
ISSN
1078-0432

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## Abstract CD19 is an attractive therapeutic target for treating human B‐cell tumors. In our study, chimeric (c) divalent (cHD37) and tetravalent (cHD37‐DcVV) anti‐CD19 monoclonal antibodies (MAbs) were constructed, expressed and evaluated for their binding to human 19‐positive (CD19^+^) tumor cel