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In Vitro and In Vivo Pharmacology and Pharmacokinetics of a Human Engineered™ Monoclonal Antibody to Epithelial Cell Adhesion Molecule

✍ Scribed by Ammons, W. Steve; Bauer, Robert J.; Horwitz, Arnold H.; Chen, Zhi J.; Bautista, Eddie; Ruan, Harry H.; Abramova, Marina; Scott, Kristen R.; Dedrick, Russell L.


Book ID
122319772
Publisher
Neoplasia Press
Year
2003
Tongue
English
Weight
136 KB
Volume
5
Category
Article
ISSN
1522-8002

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Redirected T-cell cytotoxicity to epithe
✍ Lifen Ren-Heidenreich; Pamela A. Davol; Nicola M. Kouttab; Gerald J. Elfenbein; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 290 KB 👁 1 views

## Abstract ## BACKGROUND To redirect cytotoxic T cells to target a broad range of adenocarcinomas, the authors constructed a novel, recombinant, bispecific antibody, E3Bi, directed at the tumor‐associated antigen, epithelial cell adhesion molecule (EpCAM), and the CD3 receptor on T cells. ## MET