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In vitro and in vivo mutagenicity studies on sporidesmin, the toxin associated with facial eczema in ruminants

✍ Scribed by Lynnette R. Ferguson; Jill Berriman; Amira Pearson; Rex Munday; Elizabeth A. Fowke; Neale R. Towers


Book ID
113194235
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
723 KB
Volume
268
Category
Article
ISSN
0027-5107

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Alclofenac (A) and two of its metabolites, dihydroxyalclofenac (DHA) and alclofenac epoxide (AE), were tested for their mutagenic potential. Alclofenac and DHA showed no mutagenic, transforming or clastogenic potential in any in vitro experiment. The addition of a supplementary metabolic activation