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In vitro and in vivo kinetic interactions of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid with thalidomide and diclofenac

✍ Scribed by Shufeng Zhou; James W. Paxton; Philip Kestell; Malcolm D. Tingle; Lai-Ming Ching

Publisher: Springer
Year: 2001
Tongue: English
Weight: 137 KB
Volume: 47
Category: Article
ISSN: 0344-5704
DOI: 10.1007/s002800000249

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## Abstract In this paper we report that the title compound (3) reacts with excess __N,N__‐dimethylformamide (DMF) containing two equivalents of acetic acid to afford 6‐amino‐1,2,4‐triazolo[3,4‐__f__][1,2,4]triazin‐8(7__H__)‐one (**1**). When 3‐amino‐2‐benzyl‐6‐hydrazino‐1,2,4‐triazin‐5(2__H__)‐one