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In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1β in the murine brain

✍ Scribed by Rozenn Mingam; Véronique De Smedt; Thierry Amédée; Rose-Marie Bluthé; Keith W. Kelley; Robert Dantzer; Sophie Layé


Book ID
116276084
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
478 KB
Volume
22
Category
Article
ISSN
0889-1591

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## Abstract Extracellular nucleotide di‐ and triphosphates such as ATP and ADP mediate their effects through purinergic P2 receptors belonging to either the metabotropic P2Y or the ionotropic P2X receptor family. The P2X~7~R is a unique member of the P2X family, which forms a pore in response to li