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In vitro and in vivo evaluation of the effects of PLA microparticle crystallinity on cellular response

✍ Scribed by Danielle L Biggs; Corinne S Lengsfeld; Brooks M Hybertson; Ka-yun Ng; Mark C Manning; Theodore W Randolph

Book ID: 114162541
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 558 KB
Volume: 92
Category: Article
ISSN: 0168-3659
DOI: 10.1016/s0168-3659(03)00325-0

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## Abstract Polymeric prodrugs of mPEG‐PLA‐haloperidol (methoxy poly(ethylene glycol)‐__b__‐poly (lactic acid)), self‐assemble into nanoscale micelle‐like structures in aqueous solutions. The micelles range in size from 28 to 52 nm in diameter and have been shown to be spherical in shape using cryo