Evaluation of antioxiodant drugs for the
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Laura Tinti; Adriano Spreafico; Daniela Braconi; Lia Millucci; Giulia Bernardini
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Article
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2010
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John Wiley and Sons
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English
β 334 KB
π 2 views
## Abstract Alkaptonuria (AKU) is a rare autosomal recessive disease, associated with deficiency of homogentisate 1,2βdioxygenase activity in the liver. This leads to an accumulation of homogentisic acid (HGA) and its oxidized derivatives in polymerized form in connective tissues especially in join