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In vitro and in vivo evaluation of oridonin-loaded long circulating nanostructured lipid carriers

✍ Scribed by Lejiao Jia; Jingyi Shen; Dianrui Zhang; Cunxian Duan; Guangpu Liu; Dandan Zheng; Xiaona Tian; Yue Liu; Qiang Zhang

Book ID
116542665
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
811 KB
Volume
50
Category
Article
ISSN
0141-8130

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## Abstract We have developed a parenteral delivery system for the administration of the highly promising pure antiestrogen RU 58668 (RU). Two types of nanoparticles (NP) made of biodegradable copolymers and coated with polyethylene‐glycol (PEG) chains were prepared: nanospheres (NS) (diameter, ∼11