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In vitro and In vivo Evaluation of Docetaxel Loaded Biodegradable Polymersomes

✍ Scribed by Kamal K. Upadhyay; Anant N. Bhatt; Emilio Castro; Anil K. Mishra; Krishna Chuttani; Bilikere S. Dwarakanath; Christophe Schatz; Jean-François Le Meins; Ambikanandan Misra; Sébastien Lecommandoux

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
562 KB
Volume
10
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Formulation of docetaxel (DOC), a hydrophobic anticancer drug, was successfully achieved in poly(γ‐benzyl L‐glutamate)‐block‐hyaluronan polymersomes using a simple and reproducible nanoprecipitation method. The prepared DOC loaded polymersomes (PolyDOC) was stable either in solution or in a lyophilized form, and showed controlled release behaviour over several days. PolyDOC showed high in vitro toxicity after 24 h in MCF‐7 and U87 cells compared to free DOC. Biodistribution data demonstrated that ^99m^Tc labelled PolyDOC t~1/2~ and MRT significantly increased compared to a DOC solution (DS). In addition, PolyDOC uptake in Ehrlich Ascites Tumor (EAT) tumor bearing mice was larger at each time point compared to DS, making such a polymer vesicle formulation an efficient drug nanocarrier for improved DOC cancer therapy.

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