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In vitro and in vivo evaluation of an oral system for time and/or site-specific drug delivery

โœ Scribed by M.E Sangalli; A Maroni; L Zema; C Busetti; F Giordano; A Gazzaniga

Book ID
114161161
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
130 KB
Volume
73
Category
Article
ISSN
0168-3659

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The aim of the present study was to investigate the effect of poly(acrylic acid)-cysteine (PAA-cysteine) exhibiting a molecular mass of 100 and 250 kDa and reduced glutathione (GSH) on the absorption of the P-glycoprotein (P-gp) and cytochrome P450 (CYP450) substrate paclitaxel in vitro and in vivo.