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In vitro and in vivo effects of suramin on rat prostate testosterone 5α-reductase

✍ Scribed by di Salle, E.; Zaccheo, T.; Briatico, G.; Ornati, G.

Book ID
122662122
Publisher
Elsevier Science
Year
1990
Weight
159 KB
Volume
26
Category
Article
ISSN
0277-5379

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## BACKGROUND. Steroid 5␣-reductase is implicated in the pathogenesis of benign prostatic hyperplasia (BPH). We studied the in vitro and in vivo effects of FR146687, a new inhibitor of 5␣-reductase. METHODS. Two isozymes of rat and human 5␣-reductases were expressed in 293 cells. In vivo effects o