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In vitro and in vivo effects of retrovirus-mediated transfer of the connexin 43 gene in malignant gliomas: consequences for HSVtk/GCV anticancer gene therapy

✍ Scribed by Cirenei, N; Colombo, B M; Mesnil, M; Benedetti, S; Yamasaki, H; Finocchiaro, G


Book ID
110038265
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
144 KB
Volume
5
Category
Article
ISSN
0969-7128

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Currently, there is no effective treatment for pancreatic cancer and prodrug-activating gene therapy with the herpes simplex virus thymidine kinase gene (HSV-tk) in combination with ganciclovir (GCV) has been suggested as a candidate approach against this disease. In the present study, we have evalu