The interaction of several of the fibroblast growth factors (FGFs) with polyanions is thought to be of physiological significance and has been exploited to create more stable pharmaceutical formulations of FGF-1 and -2. The extent of such phenomena throughout the 23-member FGF family is, however, un
In vitro and in vivo effects of repifermin (keratinocyte growth factor-2, KGF-2) on human carcinoma cells
โ Scribed by Ralph Alderson; Shiva Gohari-Fritsch; Hendrik Olsen; Viktor Roschke; Courtney Vance; Kevin Connolly
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 221 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0344-5704
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Keratinocyte growth factor (KGF) is a secreted member of the fibroblast growth factor (FGF) family of heparin-binding proteins. Studies reported to date indicate that it functions primarily as an important paracrine mediator of epithelial cell growth and differentiation. KGF appears to act via bindi
## Abstract A human ovarian adenocarcinoma cell line (PE04) has been established as a xenograft in nude mice. __In vitro__, this cell line is estrogen receptor (ER)โpositive and its growth is stimulated by 17 ฮฒโestradiol at concentrations between 10^โ12^ and 10^โ6^ M. When xenografted, PE04 cells r
## Abstract Overโexpression of the protoโoncogene HERโ2 (cโerbBโ2/neu) in ovarian, endometrial, and mammary carcinoma is an indicator of poor prognosis. Interactions between the epidermal growth factor (EGF) receptor and the HERโ2 protein have been described. The aim of this study was to elucidate