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In vitro and in vivo effects of a peptide mimetic (SC-47643) of RGD as an antiplatelet and antithrombotic agent

✍ Scribed by N.S. Nicholson; S.G. Panzer-Knodle; A.K. Salyers; B.B. Taite; L.W. King; M. Miyano; R.J. Gorczynski; M.H. Williams; M.E. Zupec; F.S. Tjoeng; S.P. Adams; L.P. Feigen


Book ID
119037984
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
897 KB
Volume
62
Category
Article
ISSN
0049-3848

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We examined the antithrombotic effect of KBT-3022, a novel antiplatelet agent, on photochemically induced arterial thrombosis in the guinea-pig saphenous artery, and compared its effect with that of aspirin and that of ticlopidine. Pretreatment with KBT-3022 [0.1 mg (0.2 Β΅mole), 0.3 mg (0.7 Β΅mole),