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In vitro and in vivo biocompatibility evaluation of a polyalkylimide hydrogel for soft tissue augmentation

✍ Scribed by P.A. Ramires; M.A. Miccoli; E. Panzarini; L. Dini; C. Protopapa

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
387 KB
Volume
72B
Category
Article
ISSN
1552-4973

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✦ Synopsis

Abstract

Injectable fillers are commonly used in Plastic and Reconstructive Surgery to correct serious and slight aesthetic defects due to their low invasiveness and an easy implant technique procedure. Synthetic hydrogels are proposed as filler materials for their similarity with soft tissue and to avoid many disadvantages of naturally derived materials such as short persistence, allergenicity, and immunogenicity. Our studies are focused on the biocompatibility evaluation of a polyacrylic hydrogel containing alkylimide‐amide groups and pyrogen free water (96%) (Bio‐Alcamid®) by means of the in vitro cytotoxicity and mutagenicity assays and the in vivo skin irritation, sensitization test, and subcutaneous implant. All tests conducted on Bio‐Alcamid® showed no toxicity. It is a substance easy to inject and remove; it does not migrate, and its safety allows it to be a suitable filler for the correction of slight and also very serious aesthetic defects. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 72B: 230–238, 2005

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