Species differences in in vitro and in v
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Hiroshi Komura; Masahiro Iwaki
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Article
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2008
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John Wiley and Sons
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English
โ 272 KB
๐ 1 views
Intestinal first-pass metabolism has a great impact on the bioavailability of CYP3A substrates in humans, and the in vivo impact has quantitatively been evaluated using CYP3A inhibitors or inducers. In vitro and in vivo preclinical investigations for intestinal metabolism are essential in clarifying