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In Vitro and In Vivo Assessment of Renal Drug Transporters in the Disposition of Mesna and Dimesna

✍ Scribed by Cutler, M. J.; Urquhart, B. L.; Velenosi, T. J.; Schwabedissen, H. E. Meyer zu; Dresser, G. K.; Leake, B. F.; Tirona, R. G.; Kim, R. B.; Freeman, D. J.

Book ID: 120394872
Publisher: Sage Publications
Year: 2012
Tongue: English
Weight: 462 KB
Volume: 52
Category: Article
ISSN: 0091-2700
DOI: 10.1177/0091270011400414

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This study determined if in uitro transfer of drug complexes across the everted rat small intestine would reflect the in uiuo absorption characteristics of the complex. The in uitro transfer of prednisolone in the presence of dimethyl-, diethyl-, dipropyl-, and dibutylpropionamide was in rank-order