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In vitro and in vivo antitumor activity of cetuximab in human gastric cancer cell lines in relation to epidermal growth factor receptor (EGFR) expression and mutational phenotype

โœ Scribed by Hotz, Birgit; Keilholz, Ulrich; Fusi, Alberto; Buhr, Heinz J.; Hotz, Hubert G.


Book ID
113057347
Publisher
Springer
Year
2011
Tongue
English
Weight
928 KB
Volume
15
Category
Article
ISSN
1436-3291

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## Abstract Selective tyrosine kinase inhibitors are regarded as promising antitumor agents for cancer treatment. Iressaยฎ (ZD1839) is an orally active, selective EGFRโ€TKI (epidermal growth factor receptorโ€tyrosine kinase inhibitor) that blocks signal transduction pathways implicated in cancer cell