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In vitro and in vivo antifibrotic effects of rosmarinic acid on experimental liver fibrosis

✍ Scribed by Gui-Sheng Li; Wang-Lin Jiang; Jing-Wei Tian; Gui-Wu Qu; Hai-Bo Zhu; Feng-Hua Fu


Book ID
113848537
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
692 KB
Volume
17
Category
Article
ISSN
0944-7113

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Liver fibrosis is characterized by increased synthesis, and decreased degradation, of extracellular matrix (ECM) within the injured tissue. Decreased ECM degradation results, in part, from increased expression of tissue inhibitor of metalloproteinase-1 (TIMP-1), which blocks matrix metalloproteinase