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In vitro and in vivo activities of C-terminally truncated PTH peptides reveal a disconnect between cAMP signaling and functional activity

✍ Scribed by Richard J. Murrills; Jeanne J. Matteo; Rachelle L. Samuel; Jennifer L. Andrews; Bheem M. Bhat; Valerie E. Coleburn; Yogendra P. Kharode; Frederick J. Bex


Book ID
116319046
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
681 KB
Volume
35
Category
Article
ISSN
8756-3282

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An important feature of cytochrome P450 (CYP) 2B1 is its high ability to convert the prodrug cyclophosphamide (CPA) to therapeutically cytotoxic metabolites, resulting in interstrand DNA-cross-linking and cell death. We have examined whether and how the phosphorylation of CYP2B1 influences CPA metab