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In vitro activation and differentiation of naïve CD4+ and CD8+ T cells into HCV Core- and NS3-specific armed effector cells: A new role for CD4+ T cells

✍ Scribed by Deepa K. Krishnadas; Wen Li; Rakesh Kumar; Lorne J. Tyrrell; Babita Agrawal

Book ID
113527211
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
644 KB
Volume
259
Category
Article
ISSN
0008-8749

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## Abstract To understand the inter‐individual and virus‐independent variability of CD4^+^ T cell responses to HCV components, we evaluated the effect on these responses of HLA II molecules in uninfected healthy donors. Using HLA II‐specific binding assays, we identified, in the Core and NS3 protei